She first asserted herself during a feud between Mysterio and Chavo Guerrero when Chavo accused Mysterio of being "nothing but a leech living off the blood of the Guerrero name" on the August 4 SmackDown! Following interference, Edge won the match and Vickie 'banished' Undertaker. He performed a Tombstone Piledriver on Vickie. In her TV roles as a heel manager and authority figure, Guerrero admits she wasn't very good at first, but once she hit her stride, she became the woman WWE fans loved to loathe.
After the match, McCool and Layla began to beat down Tiffany until Beth Phoenix made the save, in the process delivering a clothesline to Vickie. She has made sporadic appearances since then.